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Dry mouth, bacteria, and tooth decay Nicotine from e-cigarettes also reduces the saliva in your mouth

Bioavailability Considerations: Smoking typically provides 10-35% bioavailability, meaning a significant portion of cannabinoids are lost through combustion and exhalation

The pleiotropic effects of tobacco smoke on the immunostimulatory function of DCs are further illustrated by a study reporting a diminished capacity of DCs from cigarette smoke-exposed mice to induce IL-2 production by T cells, which was associated with a decreased antigen-specific T-cell proliferation in vivo